General Information

  • ID:  hor006927
  • Uniprot ID:  P0DP23??3-149)
  • Protein name:  Calmodulin-1
  • Gene name:  FGF2
  • Organism:  Homo sapiens
  • Family:  Calmodulin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
  • GO MF:  GO:0034704 calcium channel complex; GO:1902494 catalytic complex; GO:0005813 centrosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005576 extracellular region; GO:0043209 myelin sheath; GO:0005654 nucleoplasm; GO:0005634 nucleus; GO:0005886 plasma membrane; GO:0032991 protein-containing complex; GO:0030017 sarcomere; GO:0097225 sperm midpiece; GO:0005876 spindle microtubule; GO:0000922 spindle pole; GO:0031982 vesicle; GO:0008076 voltage-gated potassium channel complex
  • GO BP:  GO:0031432 titin binding; GO:0010856 adenylate cyclase activator activity; GO:0019855 calcium channel inhibitor activity; GO:0005509 calcium ion binding; GO:0048306 calcium-dependent protein binding; GO:0019901 protein kinase binding; GO:0072542 protein phosphatase activator activity; GO:0043539 protein serine/threonine kinase activator activity; GO:0044325 transmembrane transporter binding
  • GO CC:  GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT; GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity; GO:0050848 regulation of calcium-mediated signaling; GO:0098901 regulation of cardiac muscle cell action potential; GO:0032465 regulation of cytokinesis; GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction; GO:0035307 positive regulation of protein dephosphorylation; GO:0002027 regulation of heart rate; GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity; GO:0055117 regulation of cardiac muscle contraction; GO:0031954 positive regulation of protein autophosphorylation; GO:014

Sequence Information

  • Sequence:  DQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
  • Length:  147
  • Propeptide:  MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
  • Signal peptide:  NA
  • Modification:  T33 Sulfocysteine
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    NA

Physical Information

Mass: Formula:
Absent amino acids: Common amino acids:
pI: Basic residues:
Polar residues: Hydrophobic residues:
Hydrophobicity: Boman Index:
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index
Instability Index: Extinction Coefficient cystines:
Absorbance 280nm:

Literature

  • PubMed ID:  NA
  • Title:  NA